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Thermo Scientific™ Lab Vision™ HIF-1α (Hypoxia-Inducible Factor-1α) Ab-4, Mouse Monoclonal Antibody

Recommended for Immunohistochemistry (Formalin/paraffin), Thermo Scientific™ HIF-1α (Hypoxia-Inducible Factor-1α) Ab-4, Mouse Monoclonal Antibody provides accurate, reproducible results.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS1164PABX

 View more versions of this product

Catalog No. MS1164PABX


 

Specifications

Description

Recommended for Immunohistochemistry (Formalin/paraffin), Thermo Scientific™ HIF-1α (Hypoxia-Inducible Factor-1α) Ab-4, Mouse Monoclonal Antibody provides accurate, reproducible results.

HIF-1 (hypoxia-inducible factor-1) is a heterodimer consisting of an alpha and a β subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors. HIF-1 is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation. HIF-1 activates transcription of hypoxia-inducible genes, including those encoding: erythropoietin, vascular endothelial growth (VEGF), heme oxygenase-1, inducible nitric oxide synthase, and the glycolytic enzymes aldolase A, enolase 1, lactate dehydrogenase A, phosphofructokinase I, and phosphoglycerate kinase 1. The C-terminal of HIF-1 alpha binds to p300. p300/CBP-HIF complexes participate in the induction of hypoxia-responsive genes, including VEGF.

Host Species: Mouse

Clone: H1α67

Isotype: IgG2b/κ

Species Reactivity: Human, Sheep, Mouse, Rat and Ferret. Others not known.

Epitope: aa 432-528

Immunogen: Recombinant hHIF-1α (aa 432-528) protein

Molecular Weight: 120kDa

Positive Control: Mammalian cells cultured under reduced O2 tension

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not verified)
  • Immunoprecipitation (Not verified)

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

HIF-1alpha (Hypoxia-Inducible Factor-1alpha) Ab-4
Monoclonal
1mg/mL
Concentrated
Recombinant hHIF-1alpha (aa 432-528) protein
200μL
Transcription Regulation
Monoclonal
Immunohistochemistry (Paraffin)
H1alpha67
Unlabeled
Murine
IgG2b kappa
RUO
Primary
Ferret,Human,Murine,Rat,Sheep