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Thermo Scientific™ Lab Vision™ HER-4/c-erbB-4, Mouse Monoclonal Antibody


Recommended for Immunohistochemistry (Formalin/paraffin), Thermo Scientific™ HER-4/c-erbB-4, Mouse Monoclonal Antibody provides accurate, reproducible results.

Manufacturer: thermo scientific™ lab vision™  MS637P1ABX

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Catalog No. MS637P1ABX

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Description & Specifications

Specifications

Antigen HER-4/c-erbB-4
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone HFR-1
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Format Concentrated
Host Species Mouse
Immunogen A synthetic peptide corresponding to aa 1249-1264 (Cys-RSTLQHPDYLQEYST) from the human c-erbB-4/HER-4 oncoprotein
Isotype IgG2b
Quantity 100µL
Regulatory Status RUO
Research Discipline EGFR Family
Type Primary

Recommended for Immunohistochemistry (Formalin/paraffin), Thermo Scientific™ HER-4/c-erbB-4, Mouse Monoclonal Antibody provides accurate, reproducible results.

c-erbB-4 is the fourth member of class I receptor kinase family (ErbB). HER-4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDA-MB-330 and MDA-MB-361. Expression of erbB-4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3

Host Species: Mouse

Clone: HFR-1

Isotype: IgG2b

Species Reactivity: Human and Mouse. Others not tested.

Epitope: aa 1249-1264

Immunogen: A synthetic peptide corresponding to aa 1249-1264 (Cys-RSTLQHPDYLQEYST) from the human HER-4/c-erbB-4 oncoprotein

Molecular Weight: 185kDa

Positive Control: Breast CA or Skeletal muscle

Cellular Localization: Cytoplasmic and membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)

Note:

USA: RUO; Int'l: RUO