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Thermo Scientific™ Lab Vision™ HER-2/c-erbB-2/neu, Rabbit Monoclonal Antibody


Recommended for Immunohistochemistry (Formalin/paraffin), Thermo Scientific™ HER-2/c-erbB-2/neu, Rabbit Monoclonal Antibody is part of a comprehensive antibody portfolio. Studies show rabbit monoclonal antibodies are more sensitive and specific than other available markers.

Manufacturer: thermo scientific™ lab vision™  RM2112S0

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Catalog No. RM2112S0

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Description & Specifications

Specifications

Antigen HER-2/c-erbB-2/neu
Applications Immunohistochemistry
Clone EP1045Y
Conjugate Unlabeled
Cross Reactivity Human
Format Supernatant
Formulation Culture Supernatant with Azide
Host Species Rabbit
Immunogen A synthetic peptide corresponding to the c-terminus of human Her2
Quantity 100µL
Type Primary

Recommended for Immunohistochemistry (Formalin/paraffin), Thermo Scientific™ HER-2/c-erbB-2/neu, Rabbit Monoclonal Antibody is part of a comprehensive antibody portfolio. Studies show rabbit monoclonal antibodies are more sensitive and specific than other available markers.

HER2 gene encodes a transmembrane glycoprotein with tyrosine kinase activity. It is closely related in structure to the epidermal growth factor receptor c-erbB-3/HER3/neu oncoprotein. The protein is detectable in a subset of breast and other carcinomas (urinary bladder, stomach, lung, endometrium and ovary). In the case of breast cancer, over expression determined by immunohistochemistry has been shown to be associated with poor prognosis and an indication to initiate trastuzumab/herceptin therapy.

Host Species: Rabbit

Clone: EP1045Y

Isotype: IgG

Species Reactivity: Human. Others not tested.

Epitope: Not determined

Immunogen: A synthetic peptide corresponding to the c-terminus of human Her2

Molecular Weight: 185 kDa

Positive Control: Breast carcinomas

Cellular Localization: Cell membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)