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Thermo Scientific™ Lab Vision™ HER-2/c-erbB-2/neu (Phospho-specific) Ab-18, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu (Phospho-specific) Ab-18, Mouse Monoclonal Antibody.

$390.00 - $2,083.39

Specifications

Antigen HER-2/c-erbB-2/neu (Phospho-specific) Ab-18
Clone PN2A
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
View More Specs
Products
Catalog Number Mfr. No. Concentration Conjugate Quantity Price Quantity    

MS1072B

 
thermo scientific™ lab vision™
MS-1072-B
200�g/mL Biotin 1mL Each for $2,083.39

MS1072B0

 
thermo scientific
MS-1072-B0
200�g/mL Biotin 100µL Each for $454.04

MS1072B1

 
thermo scientific™ lab vision™
MS-1072-B1
200�g/mL Biotin 500µL Each for $1,306.02

MS1072P

 
thermo scientific™ lab vision™
MS-1072-P
200�g/mL Unlabeled 1mL Each for $1,743.37

MS1072P0

 
thermo scientific™ lab vision™
MS-1072-P0
200�g/mL Unlabeled 100µL Each for $390.00

MS1072P1

 
thermo scientific™ lab vision™
MS-1072-P1
200�g/mL Unlabeled 500µL Each for $1,108.88

MS1072P1ABX

 
thermo scientific™ lab vision™
MS1072P1ABX
1mg/mL Unlabeled 100µL Each for $1,170.88

MS1072PABX

 
thermo scientific™ lab vision™
MS1072PABX
1mg/mL Unlabeled 200µL Each for $1,857.41
Description & Specifications

Specifications

Antigen HER-2/c-erbB-2/neu (Phospho-specific) Ab-18
Clone PN2A
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Cross Reactivity Human
Cross Reactivity Rat
Cross Reactivity Human
Cross Reactivity Rat
Format Concentrated
Host Species Mouse
Regulatory Status RUO
Research Discipline EGFR Family
Type Primary
Immunogen Tyrosine-phosphorylated synthetic peptide corresponding to aa1242-1255 [Lys-TAENPE-pY-LGLDVPV] from the C-terminus of human c-erbB-2 protein (P-Tyr1248)
Isotype IgG1

Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu (Phospho-specific) Ab-18, Mouse Monoclonal Antibody.

c-erbB-2 (HER-2/neu) is a 185 kDa receptor tyrosine kinase belonging to the epidermal growth factor receptor family, which also includes EGFR (HER-1), c-erbB-3 (HER-3), and c-erbB-4 (HER-4). Amplification of the HER-2 gene with overexpression of the protein occurs in 20-30% of breast cancers, and tumor progression in mammary cancer is associated with elevated levels of tyrosine-phosphorylated neu and erbB-3. Tyr1248 is the phosphorylation site that is most tightly linked to oncogenic transformation and coupling to the ras/MAP kinase signaling pathway. Cases of invasive breast carcinoma with the phosphorylated receptor have displayed aggressive clinicopathological features and adverse prognoses. Activation of HER-2 is frequent in ductal carcinoma in situ suggesting that HER-2 signaling plays a critical role in the early stages of breast tumorigenesis.

Host Species: Mouse

Clone: PN2A

Isotype: IgG1

Species Reactivity: Human and Rat. Others not tested.

Epitope: aa 1242-1255 with pTyr

Immunogen: Tyrosine-phosphorylated synthetic peptide corresponding to aa 1242-1255 [Lys-TAENPE-pY-LGLDVPV] from the C-terminus of human HER-2 protein (P-Tyr1248)

Molecular Weight: 185 kDa

Positive Control: EGF-treated SKBR-3 cells. About 5% of breast CA are positive for phospho-HER-2/c-erbB-2/neu oncoprotein.

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Not verified)
  • Flow Cytometry (Not verified)

Note:

USA: RUO; Int'l: RUO