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Thermo Scientific™ Lab Vision™ HER-2/c-erbB-2/neu Ab-5, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-5, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS302P1ABX

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Catalog No. MS302P1ABX

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Description & Specifications

Specifications

Regulatory Status RUO
Applications Immunofluorescence
Applications Immunoprecipitation
Immunogen Intact SKBR-3 breast cancer cells
Host Species Mouse
Clone N24
Format Concentrated
Antigen HER-2/c-erbB-2/neu Ab-5
Cross Reactivity Human
Quantity 100µL
Isotype IgG1
Classification Monoclonal
Type Primary
Research Discipline EGFR Family
Concentration 1mg/mL
Conjugate Unlabeled

Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-5, Mouse Monoclonal Antibody.

c-erbB-2 is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: N24

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: Intact SKBR-3 breast cancer cells

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunofluorescence
  • Immunoprecipitation
  • Accelerates (∽50%) HER-2 Internalization
  • Inhibits (∽80%) Tumorigenic Cell Growth

Note:

USA: RUO; Int'l: RUO