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Thermo Scientific™ Lab Vision™ HER-2/c-erbB-2/neu Ab-5, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-5, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS302P1ABX

 View more versions of this product

Catalog No. MS302P1ABX


 

Specifications

Description

Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-5, Mouse Monoclonal Antibody.

c-erbB-2 is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: N24

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: Intact SKBR-3 breast cancer cells

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunofluorescence
  • Immunoprecipitation
  • Accelerates (∽50%) HER-2 Internalization
  • Inhibits (∽80%) Tumorigenic Cell Growth

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

HER-2/c-erbB-2/neu Ab-5
Monoclonal
1mg/mL
Human
Murine
IgG1
RUO
Primary
Human
Immunofluorescence,Immunoprecipitation
N24
Unlabeled
Concentrated
Intact SKBR-3 breast cancer cells
100μL
EGFR Family
Monoclonal