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Thermo Scientific™ Lab Vision™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS301P1ABX

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Catalog No. MS301P1ABX


 

Specifications

Description

Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody.

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: N12

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: Intact SKBR-3 breast cancer cells

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunofluorescence
  • Immunoprecipitation (Not suitable)
  • Inhibits Tumor Growth (∽90%)
  • Inhibits Cell Proliferation
  • Effect on HER-2 Internalization (Moderate)
  • Electron Microscopy

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

HER-2/c-erbB-2/neu Ab-4
Monoclonal
1mg/mL
Concentrated
Intact SKBR-3 breast cancer cells
100μL
EGFR Family
Monoclonal
Immunofluorescence,Immunohistochemistry (Frozen)
N12
Unlabeled
Murine
IgG1
RUO
Primary
Human