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Thermo Scientific™ Lab Vision™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS301P1ABX

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Catalog No. MS301P1ABX

  • / Each
 

Description & Specifications

Specifications

Antigen HER-2/c-erbB-2/neu Ab-4
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Classification Monoclonal
Clone N12
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Murine
Immunogen Intact SKBR-3 breast cancer cells
Isotype IgG1
Quantity 100μL
Regulatory Status RUO
Research Discipline EGFR Family
Type Primary
Monoclonal or Polyclonal Monoclonal
Target Species Human

Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody.

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: N12

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: Intact SKBR-3 breast cancer cells

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunofluorescence
  • Immunoprecipitation (Not suitable)
  • Inhibits Tumor Growth (∽90%)
  • Inhibits Cell Proliferation
  • Effect on HER-2 Internalization (Moderate)
  • Electron Microscopy

Note:

USA: RUO; Int'l: RUO