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Thermo Scientific™ Lab Vision™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS301P1ABX

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Catalog No. MS301P1ABX

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Description & Specifications

Specifications

Antigen HER-2/c-erbB-2/neu Ab-4
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Classification Monoclonal
Clone N12
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Intact SKBR-3 breast cancer cells
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline EGFR Family
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody.

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: N12

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: Intact SKBR-3 breast cancer cells

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunofluorescence
  • Immunoprecipitation (Not suitable)
  • Inhibits Tumor Growth (∽90%)
  • Inhibits Cell Proliferation
  • Effect on HER-2 Internalization (Moderate)
  • Electron Microscopy

Note:

USA: RUO; Int'l: RUO