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Thermo Scientific™ Lab Vision™ HER-2/c-erbB-2/neu Ab-2, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-2, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS229P1ABX

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Catalog No. MS229P1ABX

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Description & Specifications

Specifications

Antigen HER-2/c-erbB-2/neu Ab-2
Applications Flow Cytometry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Classification Monoclonal
Clone 9G6.10
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen RAC311 cells transfected with SV40-neu construct, expressing human neu protein
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Oncogenesis
Type Primary

Provides accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-2, Mouse Monoclonal Antibody.

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: 9G6.10

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: RAC311 cells transfected with SV40-neu construct, expressing human neu protein

Molecular Weight: 185kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Frozen only) Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry
  • Inhibits Colony Formation
  • Partially Inhibits Tyrosine Kinase Activity

Note:

USA: RUO; Int'l: RUO