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Thermo Scientific™ Lab Vision™ HER-2/c-erbB-2/neu Ab-2, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-2, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS229P1ABX

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Catalog No. MS229P1ABX

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Description & Specifications

Specifications

Antigen HER-2/c-erbB-2/neu Ab-2
Applications Flow Cytometry
Applications Immunofluorescence
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Classification Monoclonal
Clone 9G6.10
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Murine
Immunogen RAC311 cells transfected with SV40-neu construct, expressing human neu protein
Isotype IgG1
Quantity 100μL
Regulatory Status RUO
Research Discipline Oncogenesis
Type Primary
Monoclonal or Polyclonal Monoclonal
Target Species Human

Provides accurate, reproducible results with the Thermo Scientific™ HER-2/c-erbB-2/neu Ab-2, Mouse Monoclonal Antibody.

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: 9G6.10

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: RAC311 cells transfected with SV40-neu construct, expressing human neu protein

Molecular Weight: 185kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Frozen only) Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry
  • Inhibits Colony Formation
  • Partially Inhibits Tyrosine Kinase Activity

Note:

USA: RUO; Int'l: RUO