Thermo Scientific™ Lab Vision™ Heparan Sulfate Proteoglycan/Perlecan Ab-1, Rat Monoclonal Antibody
Obtain accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.
Manufacturer: Thermo Scientific™ Lab Vision™ RT794P1ABX
Obtain accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ Heparan Sulfate Proteoglycan/Perlecan Ab-1, Rat Monoclonal Antibody.Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Host Species: Rat
Species Reactivity: Human, Cow, Pig, Mouse. Others not known.
Epitope: Not determined
Immunogen: Murine EHS laminin preparation
Molecular Weight: High
Positive Control: Tonsil
Cellular Localization: Basement membrane
- Immunohistochemistry (Frozen and acid-alcohol-fixed, paraffin-embedded)
- Western Blotting (Not verified)
USA: RUO; Int'l: RUO
|Heparan Sulfate Proteoglycan/Perlecan Ab-1|
|Murine EHS laminin preparation|