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Tocris™ GSK 429286

Selective Rho-kinase (ROCK) inhibitor

$134.94 - $1,348.18

Specifications

Product Type GSK 429286
Inhibitors GSK 429286
Molecular Weight 432.37
Purity >97
View More Specs

 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

37261R

 
tocris™
3726/1
1mg Each for $134.94

372610R

 
tocris™
3726/10
10mg Each for $320.01

372650R

 
tocris™
3726/50
50mg Each for $1,348.18
Description & Specifications

Specifications

Product Type GSK 429286
Inhibitors GSK 429286
Molecular Weight 432.37
Purity >97

Selective Rho-kinase inhibitor (IC50 values are 14, 780 and 1940nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC50 = 190nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.

  • Chemical Name: 4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide
  • Formula: C21H16F4N4O2
  • CAS Number: 864082-47-3
  • Solubility: Soluble to 100mM in DMSO and to 25mM in ethanol
  • Purity: >97