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Thermo Scientific™ Lab Vision™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.

$268.47 - $1,373.53

Specifications

Antigen Grb2/sem5/ASH Signaling Protein Ab-4
Clone 2GB04; same as C1.4
Applications Immunofluorescence,Immunohistochemistry (Paraffin),Immunofluorescence,Immunohistochemistry (Paraffin)
Classification Monoclonal
Conjugate Unlabeled
View More Specs


Products ${productFamilyLength}
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
MS1457P Thermo Scientific™ Lab Vision™
MS1457P
Purified Ab with BSA and Azide 1mL Each for $1,250.14
MS1457P0 Thermo Scientific
MS1457P0
Purified Ab with BSA and Azide 100μL Each for $268.47
MS1457P1 Thermo Scientific™ Lab Vision™
MS1457P1
Purified Ab with BSA and Azide 500μL Each for $785.76
MS1457P1ABX Thermo Scientific™ Lab Vision™
MS1457P1ABX
Ab without BSA/Azide (Frozen) 100μL Each for $873.82
MS1457PABX Thermo Scientific™ Lab Vision™
MS1457PABX
Ab without BSA/Azide (Frozen) 200μL Each for $1,373.53
MS1457R7 Thermo Scientific™ Lab Vision™
MS1457R7
Ready-to-use for IHC (UVLP) 7mL Each for $748.20
Specifications

Description

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody.

Grb2 protein contains one SH2 domain flanked on both sides by an SH3 domain. Ab-1 binds to the junction between the amino terminal SH3 domain and the SH2 domain of Grb2. Reactivity with Grb2 deletion mutants suggests that its epitope maps between aa 54-62. In response to EGF, Grb2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The Grb2-Sos complex then binds the EGF-receptor. These interactions play a critical role in the activation of the p21ras signalling pathway.

Host Species: Mouse

Clone: 2GB04 (C1.4)

Isotype: IgG1/κ

Species Reactivity: Human, Cow, Mouse, Rat and Xenopus. Others not known.

Epitope: aa 54-62

Immunogen: Purified recombinant human Grb2 protein

Molecular Weight: 24-25 kDa

Positive Control: HeLa cells, Tonsil

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO

General References:

1. Schlessinger J. Current Opinion in Genetics and Development, 1994 Feb, 4(1):25-30.

2. Boulikas T. Critical Reviews in Eukaryotic Gene Expression, 1995, 5(1):1-77.

3. Chardin P et al. Febs Letters, 1995 Aug 1, 369(1):47-51.

4. Downward J. Febs Letters, 1994 Jan 31, 338(2):113-7.

b>General References:

1. Schlessinger J. Current Opinion in Genetics and Development, 1994 Feb, 4(1):25-30.

2. Boulikas T. Critical Reviews in Eukaryotic Gene Expression, 1995, 5(1):1-77.

3. Chardin P et al. Febs Letters, 1995 Aug 1, 369(1):47-51.

4. Downward J. Febs Letters, 1994 Jan 31, 338(2):113-7.

Description & Specifications

Specifications

Grb2/sem5/ASH Signaling Protein Ab-4
Immunofluorescence,Immunohistochemistry (Paraffin),Immunofluorescence,Immunohistochemistry (Paraffin)
Unlabeled
RUO
Primary
IgG2a kappa
2GB04; same as C1.4
Monoclonal
Murine
Signal Transduction
Purified recombinant human Grb2 protein