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Thermo Scientific™ Lab Vision™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.

$256.92 - $1,314.39

Specifications

Antigen Grb2/sem5/ASH Signaling Protein Ab-4
Clone 2GB04; same as C1.4
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunofluorescence
View More Specs
Products
Catalog Number Mfr. No. Formulation Quantity Price Quantity    

MS1457P

 
thermo scientific™ lab vision™
MS-1457-P
Purified Ab with BSA and Azide 1mL Each for $1,196.45

MS1457P0

 
thermo scientific
MS-1457-P0
Purified Ab with BSA and Azide 100µL Each for $256.92

MS1457P1

 
thermo scientific™ lab vision™
MS-1457-P1
Purified Ab with BSA and Azide 500µL Each for $751.84

MS1457P1ABX

 
thermo scientific™ lab vision™
MS1457P1ABX
Ab without BSA/Azide (Frozen) 100µL Each for $836.10

MS1457PABX

 
thermo scientific™ lab vision™
MS1457PABX
Ab without BSA/Azide (Frozen) 200µL Each for $1,314.39

MS1457R7

 
thermo scientific™ lab vision™
MS-1457-R7
Ready-to-use for IHC (UVLP) 7mL Each for $715.92
Description & Specifications

Specifications

Antigen Grb2/sem5/ASH Signaling Protein Ab-4
Clone 2GB04; same as C1.4
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Conjugate Unlabeled
Cross Reactivity Bovine
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Xenopus
Cross Reactivity Bovine
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Xenopus
Cross Reactivity Bovine
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Xenopus
Cross Reactivity Bovine
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Xenopus
Cross Reactivity Bovine
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Xenopus
Host Species Mouse
Regulatory Status RUO
Research Discipline Signal Transduction
Type Primary
Immunogen Purified recombinant human Grb2 protein
Isotype IgG2a kappa

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody.

Grb2 protein contains one SH2 domain flanked on both sides by an SH3 domain. Ab-1 binds to the junction between the amino terminal SH3 domain and the SH2 domain of Grb2. Reactivity with Grb2 deletion mutants suggests that its epitope maps between aa 54-62. In response to EGF, Grb2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The Grb2-Sos complex then binds the EGF-receptor. These interactions play a critical role in the activation of the p21ras signalling pathway.

Host Species: Mouse

Clone: 2GB04 (C1.4)

Isotype: IgG1/κ

Species Reactivity: Human, Cow, Mouse, Rat and Xenopus. Others not known.

Epitope: aa 54-62

Immunogen: Purified recombinant human Grb2 protein

Molecular Weight: 24-25 kDa

Positive Control: HeLa cells, Tonsil

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO

General References:

1. Schlessinger J. Current Opinion in Genetics and Development, 1994 Feb, 4(1):25-30.

2. Boulikas T. Critical Reviews in Eukaryotic Gene Expression, 1995, 5(1):1-77.

3. Chardin P et al. Febs Letters, 1995 Aug 1, 369(1):47-51.

4. Downward J. Febs Letters, 1994 Jan 31, 338(2):113-7.

b>General References:

1. Schlessinger J. Current Opinion in Genetics and Development, 1994 Feb, 4(1):25-30.

2. Boulikas T. Critical Reviews in Eukaryotic Gene Expression, 1995, 5(1):1-77.

3. Chardin P et al. Febs Letters, 1995 Aug 1, 369(1):47-51.

4. Downward J. Febs Letters, 1994 Jan 31, 338(2):113-7.