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Thermo Scientific™ Lab Vision™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.

Manufacturer: thermo scientific™ lab vision™  MS1457P1ABX

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Catalog No. MS1457P1ABX

  • / Each
 

Description & Specifications

Specifications

Isotype IgG2a kappa
Cross Reactivity Bovine
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Xenopus
Immunogen Purified recombinant human Grb2 protein
Antigen Grb2/sem5/ASH Signaling Protein Ab-4
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Format Concentrated
Host Species Mouse
Regulatory Status RUO
Clone 2GB04; same as C1.4
Quantity 100µL
Type Primary
Research Discipline Signal Transduction
Concentration 1mg/mL
Conjugate Unlabeled
Formulation Ab without BSA/Azide (Frozen)
Classification Monoclonal

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody.

Grb2 protein contains one SH2 domain flanked on both sides by an SH3 domain. Ab-1 binds to the junction between the amino terminal SH3 domain and the SH2 domain of Grb2. Reactivity with Grb2 deletion mutants suggests that its epitope maps between aa 54-62. In response to EGF, Grb2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The Grb2-Sos complex then binds the EGF-receptor. These interactions play a critical role in the activation of the p21ras signalling pathway.

Host Species: Mouse

Clone: 2GB04 (C1.4)

Isotype: IgG1/κ

Species Reactivity: Human, Cow, Mouse, Rat and Xenopus. Others not known.

Epitope: aa 54-62

Immunogen: Purified recombinant human Grb2 protein

Molecular Weight: 24-25 kDa

Positive Control: HeLa cells, Tonsil

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO