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Thermo Scientific™ Lab Vision™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.

Manufacturer: thermo scientific™ lab vision™  MS1457PABX

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Catalog No. MS1457PABX

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Description & Specifications

Specifications

Antigen Grb2/sem5/ASH Signaling Protein Ab-4
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 2GB04; same as C1.4
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Bovine
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Xenopus
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Mouse
Immunogen Purified recombinant human Grb2 protein
Isotype IgG2a kappa
Quantity 200µL
Regulatory Status RUO
Research Discipline Signal Transduction
Type Primary

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody.

Grb2 protein contains one SH2 domain flanked on both sides by an SH3 domain. Ab-1 binds to the junction between the amino terminal SH3 domain and the SH2 domain of Grb2. Reactivity with Grb2 deletion mutants suggests that its epitope maps between aa 54-62. In response to EGF, Grb2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The Grb2-Sos complex then binds the EGF-receptor. These interactions play a critical role in the activation of the p21ras signalling pathway.

Host Species: Mouse

Clone: 2GB04 (C1.4)

Isotype: IgG1/κ

Species Reactivity: Human, Cow, Mouse, Rat and Xenopus. Others not known.

Epitope: aa 54-62

Immunogen: Purified recombinant human Grb2 protein

Molecular Weight: 24-25 kDa

Positive Control: HeLa cells, Tonsil

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO