Thermo Scientific™ Lab Vision™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody
Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.
Manufacturer: Thermo Scientific™ Lab Vision™ MS1457PABX
Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ Grb2/sem5/ASH Signaling Protein Ab-4, Mouse Monoclonal Antibody.Grb2 protein contains one SH2 domain flanked on both sides by an SH3 domain. Ab-1 binds to the junction between the amino terminal SH3 domain and the SH2 domain of Grb2. Reactivity with Grb2 deletion mutants suggests that its epitope maps between aa 54-62. In response to EGF, Grb2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The Grb2-Sos complex then binds the EGF-receptor. These interactions play a critical role in the activation of the p21ras signalling pathway.
Host Species: Mouse
Clone: 2GB04 (C1.4)
Species Reactivity: Human, Cow, Mouse, Rat and Xenopus. Others not known.
Epitope: aa 54-62
Immunogen: Purified recombinant human Grb2 protein
Molecular Weight: 24-25 kDa
Positive Control: HeLa cells, Tonsil
Cellular Localization: Cytoplasmic
- Immunohistochemistry (Formalin/paraffin)
USA: RUO; Int'l: RUO
|Grb2/sem5/ASH Signaling Protein Ab-4|
|Ab without BSA/Azide (Frozen)|
|Purified recombinant human Grb2 protein|
|2GB04; same as C1.4|