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Granzyme B Rat anti-Mouse, Biotin, Clone: 16G6, eBioscience™

Rat Monoclonal Antibody

$158.05 - $404.55

Specifications

Antigen Granzyme B
Clone 16G6
Host Species Rat
Gene Alias GrzB, GrB
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5012219 Life Technologies
LS13882280
25μg Each for $158.05
501129153 Life Technologies
LS13882282
100μg Each for $404.55
Specifications

Description

The 16G6 antibody reacts with mouse Granzyme B (GrB) which is a member of the granzyme serine protease family. GrB is found in the granules of cytotoxic T cells and NK cells. Granzyme B has also been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation. GrB has been called CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. GrB is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

For intracellular staining and flow cytometric analysis with direct conjugates of anti-mouse Granzyme B, it is highly recommended to use the Foxp3 Staining Buffer Set (cat. 00-5523). Other buffers may yield varying results. For more information, please contact technical support at tech@ebioscience.com.
Description & Specifications

Specifications

Granzyme B
Rat
Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
16G6
GrzB, GrB
Flow Cytometry (Intracellular Staining),Immunohistochemistry (Formalin/Paraffin),Western Blot
Biotin
Store at 2-8°C. Do not freeze.
Monoclonal
0.5mg/mL