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Granzyme B Rat anti-Human, Clone: 496B, eBioscience™

Rat Monoclonal Antibody

$129.05 - $375.55

Specifications

Antigen Granzyme B
Clone 496B
Host Species Rat
Species Reactivity Human
Applications Immunocytochemistry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122741

 
affymetrix
14888980
25μg Each for $129.05

501122742

 
affymetrix
14888982
100μg Each for $375.55
Description & Specifications

Specifications

Antigen Granzyme B
Clone 496B
Host Species Rat
Species Reactivity Human
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The 496B antibody reacts with human Granzyme B (GrB). GrB is one of the family of serine proteases, known as granzymes, that is located in the granules of cytotoxic T cells and NK cells. Granzyme B has been described also as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation. GrB has been called CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. GrB is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.