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Granzyme B Rat anti-Human, Clone: 496B, eBioscience™

Rat Monoclonal Antibody

$120.12 - $348.48

Specifications

Antigen Granzyme B
Clone 496B
Host Species Rat
Applications Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin)
Regulatory Status RUO
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122741 Life Technologies
LS14888980
25μg Each for $120.12
501122742 Life Technologies
LS14888982
100μg Each for $348.48
Specifications

Description

The 496B antibody reacts with human Granzyme B (GrB). GrB is one of the family of serine proteases, known as granzymes, that is located in the granules of cytotoxic T cells and NK cells. Granzyme B has been described also as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation. GrB has been called CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. GrB is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.
Description & Specifications

Specifications

Granzyme B
Rat
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
496B
Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin)
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL