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Granzyme A Mouse anti-Mouse, PE-Cy7, Clone: GzA-3G8.5, eBioscience™

Mouse Monoclonal Antibody

$187.05 - $462.55

Specifications

Antigen Granzyme A
Clone GzA-3G8.5
Host Species Mouse
Gene Alias CTLA-3, Fragmentin-1, TSP-1
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123393

 
affymetrix
25583180
25μg Each for $187.05

501123394

 
affymetrix
25583182
100μg Each for $462.55
Description & Specifications

Specifications

Antigen Granzyme A
Clone GzA-3G8.5
Host Species Mouse
Gene Alias CTLA-3, Fragmentin-1, TSP-1
Species Reactivity Mouse
Applications Flow Cytometry
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PE-Cy7
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This Gza-3G8.5 monoclonal antibody reacts with mouse Granzyme A. Granzyme A is the most abundantly expressed of the ten granzyme serine proteases that have been identified in mice. Granzymes are proteins released from the granules of NK cells and cytotoxic T lymphocytes that induce death in target cells by cleavage of intracellular substrates and play a critical role in immune defense against viruses, tumors, and intracellular bacteria. Granzyme A activates caspase-independent cell death pathways morphologically similar to apoptosis and characterized by mitochondrial and DNA damage. It may also play a role in inflammation, as the precursor form of IL-1 beta (pro-IL-1 beta) is among its target substrates. Granzyme A shares overlapping substrate specificity with the closely-related Granzyme K, which is believed to account for the minimal decrease in cytotoxicity of Granzyme A-deficient CTLs.