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Granzyme A Mouse anti-Mouse, eFluor 450, Clone: GzA-3G8.5, eBioscience™

Mouse Monoclonal Antibody

$157.08 - $394.68

Specifications

Antigen Granzyme A
Clone GzA-3G8.5
Host Species Murine
Gene Alias CTLA-3, Fragmentin-1, TSP-1
Applications Flow Cytometry,Flow Cytometry (Intracellular Staining)
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124177 Life Technologies
LS48583180
25μg Each for $157.08
501124178 Life Technologies
LS48583182
100μg Each for $394.68
Specifications

Description

This Gza-3G8.5 monoclonal antibody reacts with mouse Granzyme A. Granzyme A is the most abundantly expressed of the ten granzyme serine proteases that have been identified in mice. Granzymes are proteins released from the granules of NK cells and cytotoxic T lymphocytes that induce death in target cells by cleavage of intracellular substrates and play a critical role in immune defense against viruses, tumors, and intracellular bacteria. Granzyme A activates caspase-independent cell death pathways morphologically similar to apoptosis and characterized by mitochondrial and DNA damage. It may also play a role in inflammation, as the precursor form of IL-1 beta (pro-IL-1 beta) is among its target substrates. Granzyme A shares overlapping substrate specificity with the closely-related Granzyme K, which is believed to account for the minimal decrease in cytotoxicity of Granzyme A-deficient CTLs.
Description & Specifications

Specifications

Granzyme A
Murine
Flow Cytometry,Flow Cytometry (Intracellular Staining)
eFluor 450
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL
GzA-3G8.5
CTLA-3, Fragmentin-1, TSP-1
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer