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Granzyme A Mouse anti-Human, eFluor 660, Clone: CB9, eBioscience™

Mouse Monoclonal Antibody

$187.05 - $346.55

Specifications

Antigen Granzyme A
Clone CB9
Host Species Mouse
Gene Alias CTLA-3, Fragmentin-1, TSP-1
Species Reactivity Human
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124504

 
affymetrix
50917741
25 tests Each for $187.05

501124505

 
affymetrix
50917742
100 tests Each for $346.55
Description & Specifications

Specifications

Antigen Granzyme A
Clone CB9
Host Species Mouse
Gene Alias CTLA-3, Fragmentin-1, TSP-1
Species Reactivity Human
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.06μg)/test

This CB9 monoclonal antibody reacts with human Granzyme A. Granzyme A is the most abundantly expressed of the granzyme serine proteases, which are proteins released from the granules of NK cells and cytotoxic T lymphocytes that induce death in target cells by cleavage of intracellular substrates. They play a critical role in immune defense against viruses, tumors, and intracellular bacteria. Granzyme A activates caspase-independent cell death pathways morphologically similar to apoptosis and characterized by mitochondrial and DNA damage. It may also play a role in inflammation, as the precursor form of IL-1 beta (pro-IL-1 beta) is among its target substrates. Granzyme A shares overlapping substrate specificity with the closely-related Granzyme K, which is believed to account for the minimal decrease in cytotoxicity of Granzyme A-deficient CTL.