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gpnmb Rat anti-Mouse, eFluor 660, Clone: CTSREVL, eBioscience™

Rat Monoclonal Antibody

$158.05 - $375.55

Specifications

Antigen gpnmb
Clone CTSREVL
Host Species Rat
Gene Alias Osteoactivin, DC-HIL, HGFIN
Species Reactivity Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124392

 
affymetrix
50570880
25μg Each for $158.05

501124393

 
affymetrix
50570882
100μg Each for $375.55
Description & Specifications

Specifications

Antigen gpnmb
Clone CTSREVL
Host Species Rat
Gene Alias Osteoactivin, DC-HIL, HGFIN
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This CTSREVL monoclonal antibody recognizes human GPNMB also known as Osteoactivin, DC-HIL and HGFIN. This type-1 transmembrane glycoprotein was described independently as a bone development factor, tumor related molecule, neurokinin, and immune regulator. Expressed on macrophages and dendritic cells, GPNMB is a ligand for proteoglycan Syndecan-4 (SD-4), which is found on T cells and is known to inhibit their activation and proliferation. Hence, surface expression of GPNMB by myeloid cells may be indicative of their tolerogenic properties. Various cancers express GPNMB, and it is suspected to help in immune evasion. Treatment with IL-10 and various immunosuppressive drugs (e.g., dexamethasone) upregulate GPNMB on macrophages and dendritic cells. GPNMB may also be secreted.

The CTSREVL antibody will work on paraformaldehyde-fixed cells.