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gpnmb Rat anti-Mouse, eFluor 660, Clone: CTSREVL, eBioscience™

Rat Monoclonal Antibody

$143.88 - $341.88

Specifications

Antigen gpnmb
Clone CTSREVL
Host Species Rat
Gene Alias Osteoactivin, DC-HIL, HGFIN
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124392 Life Technologies
LS50570880
25μg Each for $143.88
501124393 Life Technologies
LS50570882
100μg Each for $341.88
Specifications

Description

This CTSREVL monoclonal antibody recognizes human GPNMB also known as Osteoactivin, DC-HIL and HGFIN. This type-1 transmembrane glycoprotein was described independently as a bone development factor, tumor related molecule, neurokinin, and immune regulator. Expressed on macrophages and dendritic cells, GPNMB is a ligand for proteoglycan Syndecan-4 (SD-4), which is found on T cells and is known to inhibit their activation and proliferation. Hence, surface expression of GPNMB by myeloid cells may be indicative of their tolerogenic properties. Various cancers express GPNMB, and it is suspected to help in immune evasion. Treatment with IL-10 and various immunosuppressive drugs (e.g., dexamethasone) upregulate GPNMB on macrophages and dendritic cells. GPNMB may also be secreted.

The CTSREVL antibody will work on paraformaldehyde-fixed cells.
Description & Specifications

Specifications

gpnmb
Rat
Flow Cytometry
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL
CTSREVL
Osteoactivin, DC-HIL, HGFIN
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer