GP6 Mouse anti-Human, eFluor® 660, Clone: HY101, eBioscience™
Mouse Monoclonal Antibody
Manufacturer: Life Technologies LS50981342
Description: The HY101 monoclonal antibody reacts with the glycoprotein VI (GPVI), a 62-kDa type-I transmembrane glycoprotein that is expressed on mature megakaryotes and platelets. GPVI associates with the Fc receptor (FcR) gamma-chain to form a high affGlycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.
|PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2|
|BDPLT11, GPIV, GPVI; glycoprotein 6; platelet collagen receptor; platelet glycoprotein VI|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.