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Thermo Scientific™ Lab Vision™ γ Glutamylcysteine Synthetase (GCS)/Glutamate-cysteine Ligase Ab-1, Rabbit Polyclonal Antibody

Ensure accurate, reproducible results in western blotting and immunoprecipitation experiments.

$258.59 - $1,225.55

Specifications

Antigen Gamma Glutamylcysteine Synthetase (GCS)/Glutamate-cysteine Ligase Ab-1
Concentration 1mg/mL
Applications Western Blotting
Classification Polyclonal
Conjugate Unlabeled
View More Specs
Products
Catalog Number Mfr. No. Formulation Quantity Price Quantity    

RB1697P

 
thermo scientific™ lab vision™
RB-1697-P
Purified Ab with BSA and Azide 1mL Each for $1,142.57

RB1697P0

 
thermo scientific™ lab vision™
RB-1697-P0
Purified Ab with BSA and Azide 100µL Each for $258.59

RB1697P1

 
thermo scientific™ lab vision™
RB-1697-P1
Purified Ab with BSA and Azide 500µL Each for $727.82

RB1697P1ABX

 
thermo scientific™ lab vision™
RB1697P1ABX
Ab without BSA/Azide (Frozen) 500µL Each for $800.53

RB1697PABX

 
thermo scientific™ lab vision™
RB1697PABX
Ab without BSA/Azide (Frozen) 1mL Each for $1,225.55
Description & Specifications

Specifications

Antigen Gamma Glutamylcysteine Synthetase (GCS)/Glutamate-cysteine Ligase Ab-1
Concentration 1mg/mL
Applications Western Blotting
Classification Polyclonal
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Non-Human Primate
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Non-Human Primate
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Non-Human Primate
Format Concentrated
Host Species Rabbit
Regulatory Status RUO
Research Discipline Enzyme
Type Primary
Immunogen A synthetic peptide derived from corresponding to aa 295-313 of rat GCLC (heavy subunit of GCS)
Isotype IgG

Ensure accurate, reproducible results in western blotting and immunoprecipitation experiments with Thermo Scientific™ γ Glutamylcysteine Synthetase (GCS)/Glutamate-cysteine Ligase Ab-1, Rabbit Polyclonal Antibody.

Glutathione (GSH) plays an important role in detoxification of oxidants and toxins from the cells. In most cells GSH is synthesized de novo in two steps catalysed by Gamma Glutamylcysteine Synthetase (GCS)/Glutamate-cystein Ligase and GSH synthetase. GCS catalyses the first and rate limiting step and is important in GSH homeostasis. It is composed of two subunits: heavy and light. These subunits are coded by different genes which are controlle by different mechanisms. The heavy subunit carries the catalytic activity and can be inhibited through feedback mechanism by GSH. Binding of light subunit to heavy subunit reduces the Michaelis-Menten constant for glutamate to a physiological concentration of 1.2mM and increases the inhibitory constant for GSH.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Monkey, Mouse and Rat, Cow (weak). Others not known.

Epitope: aa 295-313

Immunogen: A synthetic peptide corresponding to aa 295-313 of rat GCLC (heavy subunit of GCS)

Molecular Weight: 73 kDa

Positive Control: Jurkat, MAD109, PC12 cells

Cellular Localization: Cytoplasmic

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO