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Alfa Aesar™ Glimepiride

A sulfonylurea hypoglecemic agent and potent potassium channel blocker

$113.20 - $505.81

Chemical Identifiers

CAS 93479-97-1
Molecular Formula C24H34N4O5S
Molecular Weight (g/mol) 490.619
MDL Number MFCD00878417
InChI Key WIGIZIANZCJQQY-UHFFFAOYSA-N
Synonym glimepiride, amaryl, glimepiridum, glimepirida, amarel, glimepirid, glimepride, endial, roname, glimepiridum latin
PubChem CID 3476
IUPAC Name 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide
SMILES CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
AAJ62032MC View Documents Alfa Aesar™
J62032MC
100mg Each for $113.20
 
AAJ6203203 View Documents Alfa Aesar™
J6203203
1g Each for $505.81
 
Description

Description

Applications
Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Solubility
Soluble in DMSO

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
Specifications

Chemical Identifiers

93479-97-1
490.619
WIGIZIANZCJQQY-UHFFFAOYSA-N
3476
CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
C24H34N4O5S
MFCD00878417
glimepiride, amaryl, glimepiridum, glimepirida, amarel, glimepirid, glimepride, endial, roname, glimepiridum latin
4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide

Specifications

White
100mg
C24H34N4O5S
14,4440
Soluble in DMSO
CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
490.619
490.62
Glimepiride
212°C to 215°C
93479-97-1
MFCD00878417
glimepiride, amaryl, glimepiridum, glimepirida, amarel, glimepirid, glimepride, endial, roname, glimepiridum latin
WIGIZIANZCJQQY-UHFFFAOYSA-N
4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide
3476
Powder
Safety and Handling

Safety and Handling

RTECSNumber : UX9363950