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Glial Fibrillary Acid Protein (GFAP) Mouse, eFluor 570, Clone: GA5, eBioscience™
Mouse Monoclonal Antibody
Manufacturer: Life Technologies LS41989282
DescriptionThis GA5 monoclonal antibody reacts with human, mouse, rat, chicken, rabbit, and pig glial fibrillary acidic protein (GFAP). This 49kDa type III intermediate filament protein is expressed in neural tissues and distinguishes astrocytes from other glial cells during central nervous system development. Three alternative splice variants of GFAP exist; however, α-GFAP is the predominant form expressed in astrocytes. GFAP can co-assemble with vimentin and nestin in astrocytes, but such associations are not required for assembly. Like other intermediate filaments, GFAP assembly is dependent on phosphorylation and dephosphorylation of the N-terminal domain. Studies have demonstrated that mutations in the GFAP gene lead to Alexander disease. Moreover, GFAP has also been shown to be overexpressed in certain glial-derived tumors.
|Glial Fibrillary Acid Protein (GFAP)|
|Human, Murine, Porcine, Rabbit, Rat, Chicken|
|Immunocytochemistry, Immunohistochemistry, Microscopy|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
For Research Use Only.