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Gibco™ BMPR1A Recombinant Human Protein DFS Item

Bone Morphogenetic Protein Receptor 1A (BMPR1A) Fc Chimera is a bioactive protein intended for use in cell culture applications

Manufacturer: gibco™  PHC9244

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For Research Use Only. Not for use in diagnostic procedures.

Catalog No. PHC9244


Description & Specifications


Accession Number NM_004329
Cross Reactivity Human
For Use With (Application) Cell Culture; Mammalian Cell Culture
Format Lyophilized
Gene ID (Entrez) BMPR1a
Molecular Weight 43.7kDa
Purification Method Sequential Chromatography
Purity 95%
Quantity 10μg
Source Human
Storage Requirements Store lyophilized human BMPR1a at 2° to 8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤ -20°C. Avoid repeated freeze/thaw cycles.
Without Additives Carrier Protein
Structural Form Recombinant/Fc Chimera/Ligand
Protein Subtype BMPs (Bone Morphogenetic Proteins) & Related Factors
Endotoxin Concentration <0.1ng/μg
Gene Alias BMPR1A
Protein Tag Untagged
Validated Application Cell Culture
Protein Family Growth Factors & Receptors
Expression System Mammalian
Biological Activity ED50 range: 0.1 to 0.3μg/mL

BMPR1A is one of the bone morphogenetic protein (BMP) receptors which are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55kDa and type II receptors of about 70-80kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

  • High purity: no interference from other proteins or contaminants
  • High biological activity: more results with less protein
  • Proven compatibility: Gibco proteins bioassayed with Gibco media
  • High Purity Recombinant Bioactive Protein: to help ensure Gibco growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein
  • High Biological Activity: in-house activity testing of Gibco Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, anti-viral, and protease assays; specific activity is determined by its ability to inhibit human BMP4 induction of alkaline phosphatase in the mouse chondrogenic cell line ATDC5

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