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GE Healthcare Capto™ Core 700

Capto Core 700 is designed for intermediate purification and polishing of viruses and other large biomolecules.

$283.96 - $865.52

Specifications

Buffer 1M NaOH, 6M Guanidine Hydrochloride, 30% Isopropanol and 70% Ethanol
Product Type Capto Core 700 chromato graphy media
Flow Rate <500cm/hr.
For Use With (Application) Intermediate purification and polishing of viruses and other large biomolecules
Ligand Type Octylamine
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

45-002-596

 
ge healthcare
17548102
100mL Each for $865.52

45-002-595

 
ge healthcare
17548101
25mL Each for $283.96
Description & Specifications

Specifications

Buffer 1M NaOH, 6M Guanidine Hydrochloride, 30% Isopropanol and 70% Ethanol
Product Type Capto Core 700 chromato graphy media
Flow Rate <500cm/hr.
For Use With (Application) Intermediate purification and polishing of viruses and other large biomolecules
Ligand Type Octylamine
Particle Size 90μm
pH Range 2 to 14
Storage Requirements 4° to 30°C
Support Type Highly Cross-linked Agarose

The novel core bead technology and multimodal, octylamine ligand give Capto Core 700 dual functionality, size exclusion, and binding chromatography in one chromatography medium (resin).

  • For intermediate purification and polishing of viruses and other large biomolecules (Mr > 700 000) in flowthrough mode.
  • Novel core bead technology allows efficient capture of contaminants while target molecules are collected in the flowthrough.
  • Significantly improved productivity and higher flow rates compared with gel filtration methods.
  • Straightforward optimization due to flowthrough chromatography and robust performance.
  • Convenient small-scale purification, process development, and scale-up using prepacked HiTrap and HiScreen columns.
  • Capto Core 700 is composed of a ligand-activated core and inactive shell.
  • The inactive shell excludes large molecules (cut off ~ Mr 700000 [700 kDa]) from entering the core through the pores of the shell.
  • These larger molecules are collected in the column flowthrough while smaller impurities bind to the internalized ligands.
  • The core of each bead is functionalized with ligands that are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core.
  • The multimodal ligands ensure strong binding with most impurities over a wide range of pH and salt concentrations.
  • Bound impurities are removed from the beads by cleaning-in-place (CIP) procedures using NaOH and in most cases, a solvent.