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Gata-3 Rat anti-Human, Mouse, Clone: TWAJ, eBioscience™

Rat Monoclonal Antibody

$158.05 - $419.05

Specifications

Antigen Gata-3
Clone TWAJ
Host Species Rat
Gene Alias Gata3
Species Reactivity Human, Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013933

 
affymetrix
14-9966-80
25μg Each for $158.05

5013934

 
affymetrix
14996682
100μg Each for $419.05
Description & Specifications

Specifications

Antigen Gata-3
Clone TWAJ
Host Species Rat
Gene Alias Gata3
Species Reactivity Human, Mouse
Applications Immunocytochemistry
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody TWAJ recognizes mouse and human Gata-3, a member of the Gata family of transcription factors. Gata-3 is a T cell-specific transcription factor important for thymic development and Th2 differentiation. Expression during embryonic development is found in the central nervous system, skin, mammary glands and kidney. During development, the expression of Gata-3 is essential as homozygous knock-out of Gata-3 is embryonic lethal. The Gata-3 is also essential for T cell commitment and survival. In the thymus, expression is found mainly on the CD4 single positive cells. During Th2 differentiation, Gata-3 binds to the IL-4 promoter as well as represses the expression of T-bet, thus inhibiting Th1 differentiation.

Alternative splice variants have been reported especially in the MCF7 cell line. The TWAJ Human/Mouse Gata-3 antibody will recognize both forms (50 and 45 kDa) of the protein.