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Gata-3 Rat anti-Human, Mouse, Clone: TWAJ, eBioscience™

Rat Monoclonal Antibody

$143.88 - $381.48

Specifications

Antigen Gata-3
Clone TWAJ
Host Species Rat
Gene Alias Gata3
Species Reactivity Human, Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013933 Life Technologies
LS14996680
25μg Each for $143.88
5013934 Life Technologies
LS14996682
100μg Each for $381.48
Specifications

Description

The monoclonal antibody TWAJ recognizes mouse and human Gata-3, a member of the Gata family of transcription factors. Gata-3 is a T cell-specific transcription factor important for thymic development and Th2 differentiation. Expression during embryonic development is found in the central nervous system, skin, mammary glands and kidney. During development, the expression of Gata-3 is essential as homozygous knock-out of Gata-3 is embryonic lethal. The Gata-3 is also essential for T cell commitment and survival. In the thymus, expression is found mainly on the CD4 single positive cells. During Th2 differentiation, Gata-3 binds to the IL-4 promoter as well as represses the expression of T-bet, thus inhibiting Th1 differentiation.

Alternative splice variants have been reported especially in the MCF7 cell line. The TWAJ Human/Mouse Gata-3 antibody will recognize both forms (50 and 45 kDa) of the protein.
Description & Specifications

Specifications

Gata-3
Rat
Human, Mouse
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
TWAJ
Gata3
Immunocytochemistry,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL