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Tocris™ Gambogic acid

Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins

$147.80 - $623.32

Specifications

Product Type Gambogic acid
Inhibitors Gambogic acid
Molecular Weight 628.75
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 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

359010R

 
tocris™
3590/10
10mg Each for $147.80

359050R

 
tocris™
3590/50
50mg Each for $623.32
Description & Specifications

Specifications

Product Type Gambogic acid
Inhibitors Gambogic acid
Molecular Weight 628.75

Natural product isolated from the Garcinia hanburyi tree. Induces apoptosis in several tumor cell lines including T47D cells. Activates caspases with an EC50 value of 0.78 - 1.64μM and competitively inhibits antiapoptotic Bcl-2 family proteins (IC50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79μM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Also blocks Kir2.1 channels (EC50 ≤ 100nM).

  • Chemical Name: (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid
  • Formula: C38H44O8
  • CAS Number: 2752-65-0
  • Solubility: Soluble to 75mM in DMSO and to 100mM in ethanol