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FR4 Rat anti-Mouse, PE-Cy7, Clone: eBio12A5, eBioscience™

Rat Monoclonal Antibody

$245.05 - $549.55

Specifications

Antigen FR4
Clone eBio12A5
Host Species Rat
Gene Alias Folate receptor 4, FOLR4, FRdelta, FRd
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5015577

 
affymetrix
25544580
25μg Each for $245.05

5015578

 
affymetrix
25544582
100μg Each for $549.55
Description & Specifications

Specifications

Antigen FR4
Clone eBio12A5
Host Species Rat
Gene Alias Folate receptor 4, FOLR4, FRdelta, FRd
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE-Cy7
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody eBio12A5 recognizes FR4, also known as Folate receptor 4, FR δ and FBP3 (folate binding protein3). FR4 is a heavily glycosylated 35 kD receptor for folic acid and the physiologic circulating form of the vitamin, N5-methyltetrahydrofolate. Natural T regs have high levels of FR4 and together with CD25 can be used to distinguish natural Tregs, effector T cells, memory-like T cells and naïve T cells. FR4hi CD25hi cells are natural Tregs with high levels of Foxp3. FR4hi CD25lo cells are identified as central memory T cells which upon stimulation can proliferate and produce large amounts of IL-2. In contrast FR4lo CD25hi secrete proinflammatory cytokines such as IFNγ and IL-17 and have been characterized as effector memory T cells.

Based on co-staining studies, the epitopes recognized by eBioTH6 (cat 51-5446) and eBio12A5 are different thereby allowing functional studies with eBioTH6 to be evaluated with eBio12A5.