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FR4 Rat anti-Mouse, FITC, Clone: eBio12A5, eBioscience™

Rat Monoclonal Antibody

$196.68 - $368.28

Specifications

Antigen FR4
Clone eBio12A5
Host Species Rat
Gene Alias Folate receptor 4, FOLR4, FRdelta, FRd
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
509835 Life Technologies
LS11544580
25μg Each for $196.68
509836 Life Technologies
LS11544582
100μg Each for $368.28
Specifications

Description

The monoclonal antibody eBio12A5 recognizes FR4, also known as Folate receptor 4, FR δ and FBP3 (folate binding protein3). FR4 is a heavily glycosylated 35 kD receptor for folic acid and the physiologic circulating form of the vitamin, N5-methyltetrahydrofolate. Natural T regs have high levels of FR4 and together with CD25 can be used to distinguish natural Tregs, effector T cells, memory-like T cells and naïve T cells. FR4hi CD25hi cells are natural Tregs with high levels of Foxp3. FR4hi CD25lo cells are identified as central memory T cells which upon stimulation can proliferate and produce large amounts of IL-2. In contrast FR4lo CD25hi secrete proinflammatory cytokines such as IFNγ and IL-17 and have been characterized as effector memory T cells.

Based on co-staining studies, the epitopes recognized by eBioTH6 (cat 51-5446) and eBio12A5 are different thereby allowing functional studies with eBioTH6 to be evaluated with eBio12A5.
Description & Specifications

Specifications

FR4
Rat
Flow Cytometry
FITC
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.5mg/mL
eBio12A5
Folate receptor 4, FOLR4, FRdelta, FRd
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer