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FR4 Rat anti-Mouse, Clone: eBioTH6, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$477.05 - $651.05

Specifications

Antigen FR4
Clone eBioTH6
Host Species Rat
Gene Alias Folate receptor 4, FOLR4 FRdelta, FRd
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014563

 
affymetrix
16-5446-82
100μg Each for $477.05

5014564

 
affymetrix
16-5446-85
500μg Each for $651.05
Description & Specifications

Specifications

Antigen FR4
Clone eBioTH6
Host Species Rat
Gene Alias Folate receptor 4, FOLR4 FRdelta, FRd
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Applications Immunoprecipitation
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The monoclonal antibody eBioTh6 recognizes FR4, also known as FR δ and FBP3 (folate binding protein3). FR4 is a heavily glycosylated 35 kD receptor for folic acid and the physiologic circulating form of the vitamin, N5-methyltetrahydrofolate. Natural T regs have high levels of FR4 and together with CD25 can be used to distinguish natural Tregs, effector T cells, memory-like T cells and naïve T cells. In vivo studies with eBioTH6 show a decrease in the number of CD4+CD25+ cells and an enhanced tumor response leading to the elimination of advanced stages of tumors.

Based on co-staining studies, the epitopes recognized by eBioTH6 and eBio12A5 (cat 51-5445) are different thereby allowing functional studies with TH6 to be evaluated with eBio12A5.