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Tocris™ FR 180204

Selective ERK inhibitor

$314.87 - $1,322.48

Specifications

Product Type FR 180204
Inhibitors FR 180204
Molecular Weight 327.34
Purity >98
View More Specs

 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

370610R

 
tocris™
3706/10
10mg Each for $314.87

370650R

 
tocris™
3706/50
50mg Each for $1,322.48
Description & Specifications

Specifications

Product Type FR 180204
Inhibitors FR 180204
Molecular Weight 327.34
Purity >98

Selective ERK inhibitor (IC50 values are 0.14 and 0.31μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α (IC50 = 10μM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα at concentrations less than 30μM. Also inhibits TGFβ-induced AP-1 activation in Mv1Lu cells (IC50 = 3.1μM).

  • Chemical Name: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
  • Formula: C18H13N7
  • CAS Number: 865362-74-9
  • Solubility: Soluble to 100mM in DMSO
  • Purity: >98