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Foxp3 Rat anti-Mouse/Rat, Clone: FJK-16s, eBioscience™

Rat Monoclonal Antibody

$183.48 - $355.08

Specifications

Antigen Foxp3
Clone FJK-16s
Host Species Rat
Gene Alias Forkhead Box P3, Scurfin, JM2, Treg
Applications Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin),Immunohistochemistry (Frozen),Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5013141 Life Technologies
LS14577380
25μg Each for $183.48
501128845 Life Technologies
LS14577382
100μg Each for $355.08
Specifications

Description

The FJK-16s antibody reacts with mouse, rat, dog, porcine, bovine and cat Foxp3 also known as FORKHEAD BOX P3, SCURFIN, and JM2; cross reactivity of this antibody to other proteins has not been determined. Foxp3, a 49-55kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in ‘scurfy’ (sf) mice. Constitutive high expression of foxP3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells.

Immunoblotting with FJK-16s antibody has mapped the epitope to amino acids 75-125 of the mouse Foxp3 protein. In the human, this region has been shown to be alternatively spliced at the mRNA level. Both the alternatively-spliced and non-spliced isoforms are present in the CD4+CD25+ subset of lymphocytes. Preliminary RT-PCR experiments have not revealed this alternatively-spliced isoform in mouse splenocytes, suggesting different gene regulation in the mouse and human.
Description & Specifications

Specifications

Foxp3
Rat
Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin),Immunohistochemistry (Frozen),Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
FJK-16s
Forkhead Box P3, Scurfin, JM2, Treg
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer