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FoxA2 Mouse anti-Human, eFluor 660, Clone: 3C10, eBioscience™

Mouse Monoclonal Antibody

$146.52 - $361.68

Specifications

Antigen FoxA2
Clone 3C10
Host Species Murine
Gene Alias Hepatocyte nuclear factor 3 beta
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124367 Life Technologies
LS50477880
25μg Each for $146.52
501124368 Life Technologies
LS50477882
100μg Each for $361.68
Specifications

Description

This 3C10 monoclonal antibody reacts with human FOXA2, which is also known as hepatocyte nuclear factor 3 beta (HNF3B). This 48kDa member of the Forkhead family of transcription factors is expressed in the liver, pancreas (islets and some acinar cells), lung, and intestine. During development, FOXA2 is necessary for lung bud and pancreatic beta cell formation. Recently, directed expression of FOXA2 in embryonic stem cells has been found to regulate the generation and differentiation of midbrain dopaminergic neurons. It has also been shown to regulate genes involved hepatic lipid metabolism, including alpha fetoprotein, albumin, and transthyretin, as well as Pdx1 in the pancreas. FOXA2 expression is negatively regulated by insulin and reports demonstrate a role for it in sporadic cases of maturity-onset diabetes of the young and the epithelial-to-mesenchymal transition in cancer.
Description & Specifications

Specifications

FoxA2
Murine
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
3C10
Hepatocyte nuclear factor 3 beta
Immunohistochemistry (Formalin/Paraffin)
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL