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Alfa Aesar™ Fasudil, 98+%

$330.01 - $923.73

Chemical Identifiers

CAS 103745-39-7
Molecular Formula C14H17N3O2S
Molecular Weight (g/mol) 291.369
MDL Number MFCD00866182
InChI Key NGOGFTYYXHNFQH-UHFFFAOYSA-N
Synonym fasudil, fasudil inn, 5-1,4-diazepane-1-sulfonyl isoquinoline, fasudilum inn-latin, 1-5-isoquinolinesulfonyl homopiperazine, unii-q0ch43pgxs, 1h-1,4-diazepine, hexahydro-1-5-isoquinolinylsulfonyl, 5-1,4-diazepan-1-ylsulfonyl isoquinoline, 5-isoquinolinesulfonyl homopiperazine, q0ch43pgxs
PubChem CID 3547
IUPAC Name 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
AAJ63525MA View Documents Alfa Aesar™
J63525MA
10mg Each for $330.01
 
AAJ63525MF View Documents Alfa Aesar™
J63525MF
50mg Each for $923.73
 
Description

Description

Applications
HA-1077 dihydrochloride has been shown to be a vasodilating agent as well as a potent inhibitor of Rock-2 (Rho-associated Kinase II), cGKI (cGMP-dependent protein kinase), PKA (cAMP-dependent protein kinase), MYLK, and CaMKII. Rho kinase signaling pathways are thought to cause invasion, migration, and proliferation of certain cells. Studies have shown this compound can also inhibit myosin light chain kinase in vitro and suppress cell rounding by myosin light chain phosphorylation. Mechanistic experiments report that HA-1077 inhibits vascular smooth muscle contraction by acting as a calcium channel protein inhibitor. HA-1077 dihydrochloride is an inhibitor of MSK1, PKC, PRK2 and Rsk-2.

Solubility
Soluble in water or DMSO

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.
Specifications

Chemical Identifiers

103745-39-7
291.369
NGOGFTYYXHNFQH-UHFFFAOYSA-N
3547
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
C14H17N3O2S
MFCD00866182
fasudil, fasudil inn, 5-1,4-diazepane-1-sulfonyl isoquinoline, fasudilum inn-latin, 1-5-isoquinolinesulfonyl homopiperazine, unii-q0ch43pgxs, 1h-1,4-diazepine, hexahydro-1-5-isoquinolinylsulfonyl, 5-1,4-diazepan-1-ylsulfonyl isoquinoline, 5-isoquinolinesulfonyl homopiperazine, q0ch43pgxs
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline

Specifications

White
103745-39-7
MFCD00866182
fasudil, fasudil inn, 5-1,4-diazepane-1-sulfonyl isoquinoline, fasudilum inn-latin, 1-5-isoquinolinesulfonyl homopiperazine, unii-q0ch43pgxs, 1h-1,4-diazepine, hexahydro-1-5-isoquinolinylsulfonyl, 5-1,4-diazepan-1-ylsulfonyl isoquinoline, 5-isoquinolinesulfonyl homopiperazine, q0ch43pgxs
NGOGFTYYXHNFQH-UHFFFAOYSA-N
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
3547
Crystalline Powder
Fasudil
10mg
C14H17N3O2S
14,3942
Soluble in water or DMSO
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
291.369
327.83
≥98%