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Thermo Scientific™ Lab Vision™ FAK (Focal Adhesion Kinase) Ab-1, Rabbit Polyclonal Antibody

Ensure accurate, reproducible results in western blotting and immunofluorescence experiments.

$277.12 - $1,218.73

Specifications

Antigen FAK (Focal Adhesion Kinase) Ab-1
Concentration 1mg/mL
Applications Immunofluorescence,Western Blotting,Immunofluorescence,Western Blotting
Classification Polyclonal
Conjugate Unlabeled
View More Specs


Products ${productFamilyLength}
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
RB477P Thermo Scientific™ Lab Vision™
RB477P
Purified Ab with BSA and Azide 1mL Each for $1,120.59
RB477P0 Thermo Scientific™ Lab Vision™
RB477P0
Purified Ab with BSA and Azide 100μL Each for $277.12
RB477P1 Thermo Scientific™ Lab Vision™
RB477P1
Purified Ab with BSA and Azide 500μL Each for $711.65
RB477P1ABX Thermo Scientific™ Lab Vision™
RB477P1ABX
Ab without BSA/Azide (Frozen) 500μL Each for $797.90
RB477PABX Thermo Scientific™ Lab Vision™
RB477PABX
Ab without BSA/Azide (Frozen) 1mL Each for $1,218.73
Specifications

Description

Ensure accurate, reproducible results in western blotting and immunofluorescence experiments with Thermo Scientific™ FAK (Focal Adhesion Kinase) Ab-1, Rabbit Polyclonal Antibody.

FAK (Focal Adhesion Associated Protein-Tyrosine Kinase) is a widely expressed non-receptor protein tyrosine kinase (PTK). FAK has a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, which are sites where cells attach to the extracellular matrix via surface integrin receptors. Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin. Adhesion of murine NIH3T3 fibroblasts to fibronectin promotes association of the Grb2 adapter protein and c-Src PTK with FAK in vivo, and also results in activation of the ERK2 MAP kinase. In v-Src-transformed NIH3T3, the association of v-Src, Grb2, and Sos with FAK is independent of cell adhesion to fibronectin. In vitro the Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK, and the binding site has been identified as Tyr925 by site directed mutagenesis.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Mouse, Rat, Dog and Frog. Others not known.

Epitope: aa 853-1052

Immunogen: Recombinant protein corresponding to aa 853-1052 from the C-terminus of human FAK

Molecular Weight: 125 kDa

Positive Control: U118, SW156, HUVEC or IMR-5 cells

Cellular Localization: Cytoplasmic and focal contacts

Recommended for:

  • Western Blotting
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO

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Description & Specifications

Specifications

FAK (Focal Adhesion Kinase) Ab-1
Immunofluorescence,Western Blotting,Immunofluorescence,Western Blotting
Unlabeled
Concentrated
RUO
Primary
IgG
1mg/mL
Polyclonal
Canine,Frog,Human,Mouse,Rat,Canine,Frog,Human,Mouse,Rat,Canine,Frog,Human,Mouse,Rat,Canine,Frog,Human,Mouse,Rat,Canine,Frog,Human,Mouse,Rat
Rabbit
Signal Transduction
Recombinant protein corresponding to aa 853-1052 from the C-terminus of human FAK