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Thermo Scientific™ Lab Vision™ FAK (Focal Adhesion Kinase) Ab-1, Rabbit Polyclonal Antibody

Ensure accurate, reproducible results in western blotting and immunofluorescence experiments.

$257.63 - $1,133.43

Specifications

Antigen FAK (Focal Adhesion Kinase) Ab-1
Concentration 1mg/mL
Applications Immunofluorescence
Applications Western Blotting
Applications Immunofluorescence
View More Specs
Products
Catalog Number Mfr. No. Formulation Quantity Price Quantity    

RB477P

 
thermo scientific™ lab vision™
RB-477-P
Purified Ab with BSA and Azide 1mL Each for $1,042.20

RB477P0

 
thermo scientific™ lab vision™
RB-477-P0
Purified Ab with BSA and Azide 100µL Each for $257.63

RB477P1

 
thermo scientific™ lab vision™
RB-477-P1
Purified Ab with BSA and Azide 500µL Each for $661.90

RB477P1ABX

 
thermo scientific™ lab vision™
RB477P1ABX
Ab without BSA/Azide (Frozen) 500µL Each for $742.02

RB477PABX

 
thermo scientific™ lab vision™
RB-477-PABX
Ab without BSA/Azide (Frozen) 1mL Each for $1,133.43
Description & Specifications

Specifications

Antigen FAK (Focal Adhesion Kinase) Ab-1
Concentration 1mg/mL
Applications Immunofluorescence
Applications Western Blotting
Applications Immunofluorescence
Applications Western Blotting
Classification Polyclonal
Conjugate Unlabeled
Cross Reactivity Canine
Cross Reactivity Frog
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Canine
Cross Reactivity Frog
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Canine
Cross Reactivity Frog
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Canine
Cross Reactivity Frog
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Cross Reactivity Canine
Cross Reactivity Frog
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Format Concentrated
Host Species Rabbit
Regulatory Status RUO
Research Discipline Signal Transduction
Type Primary
Immunogen Recombinant protein corresponding to aa 853-1052 from the C-terminus of human FAK
Isotype IgG

Ensure accurate, reproducible results in western blotting and immunofluorescence experiments with Thermo Scientific™ FAK (Focal Adhesion Kinase) Ab-1, Rabbit Polyclonal Antibody.

FAK (Focal Adhesion Associated Protein-Tyrosine Kinase) is a widely expressed non-receptor protein tyrosine kinase (PTK). FAK has a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, which are sites where cells attach to the extracellular matrix via surface integrin receptors. Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin. Adhesion of murine NIH3T3 fibroblasts to fibronectin promotes association of the Grb2 adapter protein and c-Src PTK with FAK in vivo, and also results in activation of the ERK2 MAP kinase. In v-Src-transformed NIH3T3, the association of v-Src, Grb2, and Sos with FAK is independent of cell adhesion to fibronectin. In vitro the Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK, and the binding site has been identified as Tyr925 by site directed mutagenesis.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Mouse, Rat, Dog and Frog. Others not known.

Epitope: aa 853-1052

Immunogen: Recombinant protein corresponding to aa 853-1052 from the C-terminus of human FAK

Molecular Weight: 125 kDa

Positive Control: U118, SW156, HUVEC or IMR-5 cells

Cellular Localization: Cytoplasmic and focal contacts

Recommended for:

  • Western Blotting
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO

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