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F4/80 Antigen Rat anti-Mouse, eFluor 450, Clone: BM8, eBioscience™

Rat Monoclonal Antibody

$201.55 - $448.05

Specifications

Antigen F4/80 Antigen
Clone BM8
Host Species Rat
Gene Alias EMR1, Ly71, Pan Macrophage Marker
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5016362

 
affymetrix
48480180
25μg Each for $201.55

5016363

 
affymetrix
48480182
100μg Each for $448.05
Description & Specifications

Specifications

Antigen F4/80 Antigen
Clone BM8
Host Species Rat
Gene Alias EMR1, Ly71, Pan Macrophage Marker
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate eFluor 450
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The BM8 monoclonal antibody reacts with mouse F4/80 antigen, an approximately 160kDa surface receptor. It belongs to the EGF-TM7 family of proteins. As such it contains seven EGF-like domains on its extracellular N-terminus, seven transmembrane spanning sequences, and an intracellular C-terminal domain showing homology to other TM7 superfamily members. The F4/80 antigen is expressed by a majority of mature macrophages and is one of the best markers for this population of cells. However, other cell types, such as peritoneal eosinophils, Langerhans cells, and some other dendritic cell subtypes, have been reported to express this antigen as well. Expression of F4/80 commences during early myeloid development in vivo and can be upregulated on BM cells stimulated in vitro with M-CSF. Some populations of macrophages, especially in the lymphoid microenvironment, may be devoid of F4/80.