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EZH2 Mouse, Clone: AC22, eBioscience™

Mouse Monoclonal Antibody

$159.72 - $402.60

Specifications

Antigen EZH2
Clone AC22
Host Species Murine
Gene Alias Enhancer Of Zeste Homolog 2 (Drosophila)
Applications Immunocytochemistry,Immunohistochemistry,Immunoprecipitation,Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122892 Life Technologies
LS14986780
25μg Each for $159.72
501122893 Life Technologies
LS14986782
100μg Each for $402.60
Specifications

Description

The monoclonal antibody AC22 recognizes EZH2 (Enhancer of zeste homolog 2), a member of the polycomb group (PcG) proteins responsible for repression of gene expression through recognition and modification of histone methylation and chromatin structure. EZH2 comprises the catalytic subunit of the polycomb repressive complex 2 (PRC2) and directly represses gene expression through methylation of histone H3 on lysine 27 (H3K27) as well as direct protein targets such as GATA4. The PRC2 complex gene repression is necessary for proper development and differentiation. Underexpression of EZH2 is linked to abnormal developmental patterning and a loss of stem cell pluripotency, while overexpression of EZH2 is present in many tumors and correlates with poor prognosis in melanoma, breast, and prostate cancer.
Description & Specifications

Specifications

EZH2
Murine
Immunocytochemistry,Immunohistochemistry,Immunoprecipitation,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
AC22
Enhancer Of Zeste Homolog 2 (Drosophila)
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer