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EZH2 Mouse, Clone: AC22, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $433.55

Specifications

Antigen EZH2
Clone AC22
Host Species Mouse
Gene Alias Enhancer Of Zeste Homolog 2 (Drosophila)
Species Reactivity Human, Mouse, Rat
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122892

 
affymetrix
14986780
25μg Each for $172.55

501122893

 
affymetrix
14986782
100μg Each for $433.55
Description & Specifications

Specifications

Antigen EZH2
Clone AC22
Host Species Mouse
Gene Alias Enhancer Of Zeste Homolog 2 (Drosophila)
Species Reactivity Human, Mouse, Rat
Applications Immunocytochemistry
Applications Immunohistochemistry
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody AC22 recognizes EZH2 (Enhancer of zeste homolog 2), a member of the polycomb group (PcG) proteins responsible for repression of gene expression through recognition and modification of histone methylation and chromatin structure. EZH2 comprises the catalytic subunit of the polycomb repressive complex 2 (PRC2) and directly represses gene expression through methylation of histone H3 on lysine 27 (H3K27) as well as direct protein targets such as GATA4. The PRC2 complex gene repression is necessary for proper development and differentiation. Underexpression of EZH2 is linked to abnormal developmental patterning and a loss of stem cell pluripotency, while overexpression of EZH2 is present in many tumors and correlates with poor prognosis in melanoma, breast, and prostate cancer.