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Estrogen Receptor alpha Mouse anti-Human, Clone: tbykt, eBioscience™

Mouse Monoclonal Antibody

$133.32 - $348.48

Specifications

Antigen Estrogen Receptor alpha
Clone tbykt
Host Species Murine
Gene Alias ERa
Applications Immunocytochemistry,Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin),Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122807 Life Technologies
LS14974080
25μg Each for $133.32
501122808 Life Technologies
LS14974082
100μg Each for $348.48
Specifications

Description

The tbykt monoclonal antibody reacts with the human Estrogen Receptor alpha (ERa) molecule. Estrogen receptor is a member of the superfamily of nuclear receptors, which are ligand-dependent transcription factors. The human estrogen receptor becomes activated following the binding of estrogen, causing a dissociation of the chaperone protein (Hsp90) and dimerization with either ERa or ERb. The alpha and beta receptors share some homology within their DNA- and ligand- binding domains, but signal in different ways and play different roles in gene regulation. Following activation, Era can directly bind to DNA through EREs (estrogen response elements) or through a more indirect pathway by binding to other transcription factors (Sp1, AP-1, NF-kB, FoxA1 and others). Era binding to DNA can either upregulate or repress gene expression. The alpha receptor has been implicated in the development and progression of breast cancer and its presence is indicative of improved survival and a better response to endocrine therapy (anti-estrogen therapy- tamoxifen).
Description & Specifications

Specifications

Estrogen Receptor alpha
Murine
Immunocytochemistry,Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin),Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
tbykt
ERa
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer