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Thermo Scientific™ Lab Vision™ Estrogen Receptor Ab-16, Rabbit Polyclonal Antibody


Obtain accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments.

Manufacturer: thermo scientific™ lab vision™  RB1493PABX

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Catalog No. RB1493PABX

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Description & Specifications

Specifications

Host Species Rabbit
Applications Immunoprecipitation
Applications Western Blotting
Isotype IgG
Quantity 1mL
Cross Reactivity Hamster
Cross Reactivity Human
Immunogen A synthetic peptide derived from the C-terminus of human estrogen receptor, alpha protein
Format Concentrated
Regulatory Status RUO
Antigen Estrogen Receptor Ab-16
Type Primary
Formulation Ab without BSA/Azide (Frozen)
Research Discipline Steroids Hormones and Growth Factors
Conjugate Unlabeled
Classification Polyclonal
Concentration 1mg/mL
Item Description 1mL; 1mg/mL; Purified w/o BSA, azide

Obtain accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments with Thermo Scientific™ Estrogen Receptor Ab-16, Rabbit Polyclonal Antibody.

The ER gene consists of more than 140kb of genomic DNA divided into 8 exons and is translated into a protein with six functionally discrete domains required for transcription activation function, binding to estrogen response element (ERE) constitutive dimerization, binding to heat shock proteins, and ligand recognition. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Mouse and Hamster. Does not react with rat. Others not known.

Epitope: C-terminal

Immunogen: A synthetic peptide derived from the C-terminus of human estrogen receptor, α protein

Molecular Weight: 67 kDa

Positive Control: MCF-7 cells, Breast CA

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Denatured verified)
  • Gel Supershift (Not verified)

Note:

USA: RUO; Int'l: RUO