Thermo Scientific™ Lab Vision™ Estrogen Receptor Ab-16, Rabbit Polyclonal Antibody
Obtain accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments.
Manufacturer: Thermo Scientific™ Lab Vision™ RB1493PABX
Obtain accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments with Thermo Scientific™ Estrogen Receptor Ab-16, Rabbit Polyclonal Antibody.
The ER gene consists of more than 140kb of genomic DNA divided into 8 exons and is translated into a protein with six functionally discrete domains required for transcription activation function, binding to estrogen response element (ERE) constitutive dimerization, binding to heat shock proteins, and ligand recognition. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.
Host Species: Rabbit
Species Reactivity: Human, Mouse and Hamster. Does not react with rat. Others not known.
Immunogen: A synthetic peptide derived from the C-terminus of human estrogen receptor, α protein
Molecular Weight: 67 kDa
Positive Control: MCF-7 cells, Breast CA
Cellular Localization: Nuclear
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Immunoprecipitation (Denatured verified)
- Gel Supershift (Not verified)
USA: RUO; Int'l: RUO
|Estrogen Receptor Ab-16|
|Ab without BSA/Azide (Frozen)|
|A synthetic peptide derived from the C-terminus of human estrogen receptor, alpha protein|
|Steroids Hormones and Growth Factors|