Thermo Scientific™ Lab Vision™ Estrogen Receptor Ab-10, Mouse Monoclonal Antibody
Ensure accurate, reproducible results in western blotting, immunoprecipitation, gel supershift and chromatin precipitation experiments.
Manufacturer: Thermo Scientific™ Lab Vision™ MS315P1ABX
Ensure accurate, reproducible results in western blotting, immunoprecipitation, gel supershift and chromatin precipitation experiments with Thermo Scientific™ Estrogen Receptor Ab-10, Mouse Monoclonal Antibody.The ER gene consists of more than 140kb of genomic DNA divided into 8 exons and is translated into a protein with six functionally discrete domains required for transcription activation function, binding to estrogen response element (ERE) constitutive dimerization, binding to heat shock proteins, and ligand recognition. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.
Host Species: Mouse
Species Reactivity: Human, Cow, Pig, Dog, Mouse, Rat, Sheep, Rabbit, Hamster and Chicken. Others not known.
Epitope: aa 302-553
Immunogen: 35 kDa, C-terminal fragment (aa 302-595) of human ER expressed in E. coli
Molecular Weight: 67 kDa
Positive Control: T47D cells
Cellular Localization: Nuclear
- Western Blotting
- Immunoprecipitation (Native and denatured)
- Gel Supershift
- Blocks Binding of Estrogen to ER
- Chromatin Precipitation
USA: RUO; Int'l: RUO
|Estrogen Receptor Ab-10|
|35kDa, C-terminal fragment (aa 302-595) of human ER expressed in E. coli|
|Steroids Hormones and Growth Factors|