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Thermo Scientific™ Lab Vision™ Estrogen Receptor Ab-10, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in western blotting, immunoprecipitation, gel supershift and  chromatin precipitation experiments.

Manufacturer: thermo scientific™ lab vision™  MS315P1ABX

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Catalog No. MS315P1ABX

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Description & Specifications

Specifications

Antigen Estrogen Receptor Ab-10
Applications Immunoprecipitation
Classification Monoclonal
Clone TE111.5D11
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Bovine
Cross Reactivity Canine
Cross Reactivity Chicken
Cross Reactivity Hamster
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Porcine
Cross Reactivity Rabbit
Cross Reactivity Rat
Cross Reactivity Sheep
Format Concentrated
Host Species Mouse
Immunogen 35kDa, C-terminal fragment (aa 302-595) of human ER expressed in E. coli
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Steroids Hormones and Growth Factors
Type Primary

Ensure accurate, reproducible results in western blotting, immunoprecipitation, gel supershift and chromatin precipitation experiments with Thermo Scientific™ Estrogen Receptor Ab-10, Mouse Monoclonal Antibody.

The ER gene consists of more than 140kb of genomic DNA divided into 8 exons and is translated into a protein with six functionally discrete domains required for transcription activation function, binding to estrogen response element (ERE) constitutive dimerization, binding to heat shock proteins, and ligand recognition. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.

Host Species: Mouse

Clone: TE111.5D11

Isotype: IgG1

Species Reactivity: Human, Cow, Pig, Dog, Mouse, Rat, Sheep, Rabbit, Hamster and Chicken. Others not known.

Epitope: aa 302-553

Immunogen: 35 kDa, C-terminal fragment (aa 302-595) of human ER expressed in E. coli

Molecular Weight: 67 kDa

Positive Control: T47D cells

Cellular Localization: Nuclear

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Native and denatured)
  • Gel Supershift
  • Blocks Binding of Estrogen to ER
  • Chromatin Precipitation

Note:

USA: RUO; Int'l: RUO