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Thermo Scientific™ Lab Vision™ ERCC1 Ab-1, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in western blotting and immunoprecipitation experiments with Thermo Scientific™ ERCC1 Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS647P1ABX

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Catalog No. MS647P1ABX

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Description & Specifications

Specifications

Antigen ERCC1 Ab-1
Applications Immunoprecipitation
Classification Monoclonal
Clone 3H11
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Full length recombinant human ERCC1 protein
Isotype IgG2a kappa
Quantity 100µL
Regulatory Status RUO
Research Discipline DNA Repair
Type Primary

Ensure accurate, reproducible results in western blotting and immunoprecipitation experiments with Thermo Scientific™ ERCC1 Ab-1, Mouse Monoclonal Antibody.

The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision. Elevated levels of ERCC1 have also been reported in Cisplatin-resistant cells.

Host Species: Mouse

Clone: 3H11

Isotype: IgG2a/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Full-length recombinant human ERCC1 protein

Molecular Weight: 33-36 kDa

Positive Control: A431 or HeLa cells

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO