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Manufacturer: Life Technologies LSPV3626
DescriptionOncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine subfamily that includes EGFR, ERBB2, and ERBB3. ERBB4 binds and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation.
|Oncology and genetic disease research, pharma and biopharma, protein assays and analysis, target and lead identification and validation|
|85% by SDS-PAGE|
|ERBB4 was pre-diluted in enzyme dilution buffer and assayed in 12.5mM Tris (pH 7.5), 10 MgCl2, 1mM EGTA, 0.5mM Na3VO4, 5mM β-glycerophosphate, 2mM DTT, 0.01% Triton™ X-100, 200μM ATP, 200μg/mL poly [Glu, Tyr] 4:1 substrate and trace [32P]-γ-ATP for 10 minutes at 30°C|
|Kinase and inhibitors|
|EGF receptor (ErbB)|
|For research use only. Not for use in diagnostic procedures|
|Receptor tyrosine kinases|
|Amino acids 708-993|
|550nmoles of phosphate transferred to poly [Glu, Tyr] 4:1 substrate per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 2μg/mL|
For Research Use Only. Not for use in diagnostic procedures.