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Manufacturer: Life Technologies LSPV3366
DescriptionErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.
|Oncology and genetic disease research, pharma and biopharma, protein assays and analysis, target and lead identification and validation|
|70% by SDS-PAGE|
|ErbB2 (HER2), NEU|
|ERBB2 (HER2) was pre-diluted in enzyme dilution buffer and assayed in 20mM Tris (pH 7.5), 5 MnCl2, 1mM EGTA, 0.5mM Na3VO4, 5mM β−glycerophosphate, 2mM DTT, 0.01% CHAPS, 200μM ATP, 1000μg/mL poly [Glu, Tyr] 4:1 substrate and trace [32P]-γ-ATP for 10 minutes at 30°C|
|Kinases and inhibitors|
|EGF Receptor (ErbB) kinase family|
|For research use only. Not for use in diagnostic procedures|
|Receptor tyrosine kinases|
|aa 676 to 1255|
|91nmoles of phosphate transferred to poly [Glu, Tyr] 4:1 substrate per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 8.33μg/mL|
For Research Use Only. Not for use in diagnostic procedures.