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ErbB2 (HER2) DFS Item

ErbB2 (HER2)

Manufacturer:  Life Technologies LSPV3366

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Catalog No. PV3366



Description

Description

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.
Specifications

Specifications

NP_004439
Oncology and genetic disease research, pharma and biopharma, protein assays and analysis, target and lead identification and validation
68.6kDa
70% by SDS-PAGE
–80°C
1 Each
ErbB2 (HER2), NEU
ERBB2 (HER2) was pre-diluted in enzyme dilution buffer and assayed in 20mM Tris (pH 7.5), 5 MnCl2, 1mM EGTA, 0.5mM Na3VO4, 5mM β−glycerophosphate, 2mM DTT, 0.01% CHAPS, 200μM ATP, 1000μg/mL poly [Glu, Tyr] 4:1 substrate and trace [32P]-γ-ATP for 10 minutes at 30°C
Kinases and inhibitors
EGF Receptor (ErbB) kinase family
ErbB2 (HER2)
Human
0.50mg/mL
2064
ERBB2 (HER2)
10μg
For research use only. Not for use in diagnostic procedures
Receptor tyrosine kinases
ErbB2 (HER2)
Kinase assay
Baculovirus
aa 676 to 1255
91nmoles of phosphate transferred to poly [Glu, Tyr] 4:1 substrate per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 8.33μg/mL
His Tag
Documents

For Research Use Only. Not for use in diagnostic procedures.