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Thermo Scientific™ Lab Vision™ Epidermal Growth Factor Receptor/EGFR Ab-3, Mouse Monoclonal Antibody


Obtain accurate, reproducible results in immunohistochemistry, immunofluorescence, immunoprecipitation and flow cytometry experiments.

Manufacturer: thermo scientific™ lab vision™  MS311P1ABX

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Catalog No. MS311P1ABX

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Description & Specifications

Specifications

Host Species Mouse
Quantity 100µL
Clone EGFR.1
Applications Flow Cytometry
Immunogen A431 human epidermoid cells
Isotype IgG2b kappa
Cross Reactivity Equine
Cross Reactivity Human
Antigen Epidermal Growth Factor Receptor/EGFR Ab-3
Regulatory Status RUO
Format Concentrated
Research Discipline EGFR Family
Type Primary
Classification Monoclonal
Concentration 1mg/mL
Conjugate Unlabeled

Obtain accurate, reproducible results in immunohistochemistry, immunofluorescence, immunoprecipitation and flow cytometry experiments with Thermo Scientific™ Epidermal Growth Factor Receptor/EGFR Ab-3, Mouse Monoclonal Antibody.

EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Host Species: Mouse

Clone: EGFR.1

Isotype: IgG2b/κ

Species Reactivity: Human and Horse. Does not react with mouse. Others not known.

Epitope: aa 6-273

Immunogen: A431 human epidermoid cells

Molecular Weight: 170 kDa (wild type)

Positive Control: A431 cells express only the intact and not the vIII variant of EGFR. HC2 20 d2 cells express the vIII variant. In normal breast, ducts and lobules show diffuse cytoplasmic staining.

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Frozen only)
  • Western Blotting (Not suitable)
  • Immunofluorescence
  • Immunoprecipitation (Native only)
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO