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Thermo Scientific™ Lab Vision™ Epidermal Growth Factor Receptor/EGFR Ab-3, Mouse Monoclonal Antibody


Obtain accurate, reproducible results in immunohistochemistry, immunofluorescence, immunoprecipitation and flow cytometry experiments.

Manufacturer: thermo scientific™ lab vision™  MS311P1ABX

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Catalog No. MS311P1ABX

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Description & Specifications

Specifications

Antigen Epidermal Growth Factor Receptor/EGFR Ab-3
Applications Flow Cytometry
Classification Monoclonal
Clone EGFR.1
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Equine
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen A431 human epidermoid cells
Isotype IgG2b kappa
Quantity 100µL
Regulatory Status RUO
Research Discipline EGFR Family
Type Primary

Obtain accurate, reproducible results in immunohistochemistry, immunofluorescence, immunoprecipitation and flow cytometry experiments with Thermo Scientific™ Epidermal Growth Factor Receptor/EGFR Ab-3, Mouse Monoclonal Antibody.

EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Host Species: Mouse

Clone: EGFR.1

Isotype: IgG2b/κ

Species Reactivity: Human and Horse. Does not react with mouse. Others not known.

Epitope: aa 6-273

Immunogen: A431 human epidermoid cells

Molecular Weight: 170 kDa (wild type)

Positive Control: A431 cells express only the intact and not the vIII variant of EGFR. HC2 20 d2 cells express the vIII variant. In normal breast, ducts and lobules show diffuse cytoplasmic staining.

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Frozen only)
  • Western Blotting (Not suitable)
  • Immunofluorescence
  • Immunoprecipitation (Native only)
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO