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Thermo Scientific™ Lab Vision™ Epidermal Growth Factor Receptor/EGFR Ab-2, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in immunoprecipitation experiments with Thermo Scientific™ Epidermal Growth Factor Receptor/EGFR Ab-2, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS269P1ABX

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Catalog No. MS269P1ABX

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Description & Specifications

Specifications

Antigen Epidermal Growth Factor Receptor/EGFR Ab-2
Applications Immunoprecipitation
Classification Monoclonal
Clone 225
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Non-Human Primate
Format Concentrated
Host Species Mouse
Immunogen Purified EGFR from A431 cells
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline EGFR Family
Type Primary

Ensure accurate, reproducible results in immunoprecipitation experiments with Thermo Scientific™ Epidermal Growth Factor Receptor/EGFR Ab-2, Mouse Monoclonal Antibody.

EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Host Species: Mouse

Clone: 225

Isotype: IgG1

Species Reactivity: Human, Chimpanzee and Monkey. Does not react with mouse and rat. Others not known.

Epitope: Extracellular domain

Immunogen: Purified EGFR from A431 cells

Molecular Weight: 170 kDa (wild type) and 145 kDa (vIII variant)

Positive Control: A431 cells

Cellular Localization: Membrane

Recommended for:

  • Immunoprecipitation (Native only)
  • Blocks EGF/TGFα-Induced Activation of EGFR
  • Arrests Tumor Growth in vivo
  • Inhibits Binding of Ab-1 (clone 528) to EGFR

Note:

USA: RUO; Int'l: RUO