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Thermo Scientific™ Lab Vision™ Epidermal Growth Factor Receptor/EGFR Ab-10, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments.

Manufacturer: thermo scientific™ lab vision™  MS378P1ABX

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Catalog No. MS378P1ABX

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Description & Specifications

Specifications

Antigen Epidermal Growth Factor Receptor/EGFR Ab-10
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Classification Monoclonal
Clone 111.6
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Mouse
Immunogen Extracellular domain of human recombinant EGFR protein
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline EGFR Family
Type Primary

Ensure accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments with Thermo Scientific™ Epidermal Growth Factor Receptor/EGFR Ab-10, Mouse Monoclonal Antibody.

EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Host Species: Mouse

Clone: 111.6

Isotype: IgG1

Species Reactivity: Human. Not mouse and rat.

Epitope: Extracellular domain

Immunogen: Extracellular domain of human recombinant EGFR protein

Molecular Weight: 170 kDa (wild type) and 145 kDa (vIII variant)

Positive Control: A431 cells; Skin, Placenta or Squamous cell CA

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Native only)
  • Effect on EGF Binding (Inhibitory)

Note:

USA: RUO; Int'l: RUO