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Thermo Scientific™ Lab Vision™ Epidermal Growth Factor Receptor/EGFR Ab-1, Mouse Monoclonal Antibody


Obtain accurate, reproducible results in affinity purification, immunoprecipitation and flow cytometry experiments.

Manufacturer: thermo scientific™ lab vision™  MS268P1ABX

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Catalog No. MS268P1ABX

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Description & Specifications

Specifications

Antigen Epidermal Growth Factor Receptor /EGFR Ab-1
Applications Flow Cytometry
Applications Immunoprecipitation
Classification Monoclonal
Clone 528
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Canine
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Purified EGFR from A431 cells
Isotype IgG2a
Quantity 100µL
Regulatory Status RUO
Research Discipline EGFR Family
Type Primary

Obtain accurate, reproducible results in affinity purification, immunoprecipitation and flow cytometry experiments with Thermo Scientific™ Epidermal Growth Factor Receptor/EGFR Ab-1, Mouse Monoclonal Antibody.

EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Host Species: Mouse

Clone: 528

Isotype: IgG2a

Species Reactivity: Human and Dog. Does not react with mouse and rat. Others not known.

Epitope: Extracellular domain

Immunogen: Purified EGFR from A431 cells

Molecular Weight: 170 kDa (wild type) and 145 kDa (vIII variant)

Positive Control: A431 cells

Cellular Localization: Membrane

Recommended for:

  • Western Blotting (Not suitable)
  • Affinity Purification
  • Blocks EGF/TGFα-induced Activation of EGFR
  • Inhibits Binding of EGFR Ab-2 (clone 225) to EGFR
  • Inhibits Proliferation of A431 Cells
  • Arrests Tumor Growth in vivo
  • Immunoprecipitation (Native only)
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO