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Epidermal Growth Factor Receptor-2 (ErbB2/HER-2) Mouse anti-Human, Clone: MJD2, eBioscience™

Mouse Monoclonal Antibody

$146.52 - $361.68

Specifications

Antigen Epidermal Growth Factor Receptor-2 (ErbB2/HER-2)
Clone MJD2
Host Species Murine
Gene Alias HER2
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122827 Life Technologies
LS14975780
25μg Each for $146.52
501122828 Life Technologies
LS14975782
100μg Each for $361.68
Specifications

Description

This MJD2 monoclonal antibody reacts with HER-2, the product of the ErbB2 gene and a member of the human epidermal growth factor receptor (EGFR) family. HER-2 is a 185kDa transmembrane receptor with an extracellular binding domain and an intracellular tyrosine kinase domain. Activation of HER-2 occurs following formation of homodimers or heterodimers with ligand-bound EGFR family members, HER3 or HER4. Overexpression of HER-2 results in auto-phosphorylation and increased proliferation and invasiveness and is associated with subsets of multiple cancer types such as breast, ovarian, cervical, uterine, and gastric. The use of HER-2 targeted agents has been used extensively to treat HER-2-positive breast cancer, but a recent study found that these agents can also block the proliferation of breast cancer stem cells found in HER-2-negative patients and suggests the importance of HER-2 as a target for multiple types of breast cancer. The MJD2 antibody recognizes the extracellular domain of HER-2 but at an epitope distinct from that recognized by the 4D5 (Herceptin) and SP3 monoclonal antibodies.
Description & Specifications

Specifications

Epidermal Growth Factor Receptor-2 (ErbB2/HER-2)
Murine
Human
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
MJD2
HER2
Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Microscopy,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL