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EIF2AK2 (PKR) Recombinant Human Protein 
EIF2AK2 (PKR) Recombinant Human Protein
Manufacturer: Life Technologies LSPV4821
Description
EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection.Specifications
| NP_002750.1 | |
| Pharma and biopharma, protein assays and analysis, target and lead identification and validation | |
| 62.2kDa | |
| 75% by SDS-PAGE | |
| –80°C | |
| 1 Each | |
| EIF2AK2 (PKR) | |
| EIF2AK2 (PKR) was pre-diluted in enzyme dilution buffer and assayed in 20mM Tris (pH 7.5), 10mM MgCl2, 1mM EGTA, 1mM Na3VO4, 5mM β−glycerophosphate, 2mM DTT, 0.02% Triton™ X-100, 200μM ATP, 267μg/mL RS domain derived peptide substrate (GRSRSRSRSR) and trace [32P]-γ-ATP for 10 minutes at 30°C | |
| Kinases and inhibitors | |
| PEK kinase family | |
| EIF2AK2 (PKR) Recombinant Human Protein | |
| Human |
| 0.13mg/mL | |
| 9833 | |
| EIF2AK2 (PKR) Recombinant Human Protein | |
| 10μg | |
| For research use only. Not for use in diagnostic procedures | |
| Serine/threonine kinase | |
| EIF2AK2 (PKR) Recombinant Human Protein | |
| Kinase assay | |
| Baculovirus | |
| aa 252 to 551 | |
| 2170nmoles of phosphate transferred to RS domain derived peptide substrate (GRSRSRSRSR) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 0.167μg/mL | |
| GST Tag |
For Research Use Only. Not for use in diagnostic procedures.