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EGFR Mouse anti-Human, eFluor 660, Clone: me1B3, eBioscience™

Mouse Monoclonal Antibody

$170.28 - $394.68

Specifications

Antigen EGFR
Clone me1B3
Host Species Murine
Gene Alias ErbB1, Her1
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124513 Life Technologies
LS50950942
100 Tests Each for $394.68
501124512 Life Technologies
LS50950941
25 Tests Each for $170.28
Specifications

Description

This me1B3 monoclonal antibody reacts with human epidermal growth factor receptor (EGFR), also known as ErbB1 and Her1. EGFR is a receptor tyrosine kinase belonging to the EGFR/ErbB receptor subfamily, which also includes ErbB2/Her2/neu. EGFR contains an extracellular ligand-binding domain, a single transmembrane-spanning region, and a cytoplasmic tail containing a tyrosine kinase domain. Specific ligands include EGF and TNF alpha, as well as other members of the EGF protein family. Upon ligand binding, EGFR undergoes receptor-mediated dimerization with itself or ErbB2/Her2/neu. Dimerization induces auto-phosphorylation, resulting in the activation of PLC gamma, JAK/STAT, MAPK/ERK, and PI3K/AKT signaling pathways. EGFR has a role in cell proliferation, migration and differentiation, and is evolutionarily highly conserved in structure and function. EGFR is broadly expressed and is overexpressed or mutated in glioblastomas and a number of different epithelial cancers, including non-small cell lung cancer and colorectal cancer.
Description & Specifications

Specifications

EGFR
Murine
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
me1B3
ErbB1, Her1
Flow Cytometry
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.125μg)/test