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EGFR (ErbB1) [T790M] Recombinant Human Protein, Invitrogen™ DFS Item

EGFR (ErbB1) [T790M] Recombinant Human Protein

Manufacturer:  Life Technologies LSPV4803

Catalog No. PV4803



Description

Description

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The T790M mutant of EGFR has arisen in the clinics and displays resistance to Erlotinib (Tarceva) and Gefitinib (Iressa).
Specifications

Specifications

NP_005219.2; T790M
Pharma and biopharma, protein assays and analysis, target and lead identification and validation
90.5kDa
70% by SDS-PAGE
–80°C
1 Each
EGFR (ErbB1) T790M
EGFR T790M was pre-diluted in enzyme dilution buffer and assayed in 25mM HEPES (pH 7.5), 10mM MgCl2, 0.5mM EGTA, 0.5mM Na3VO4, 5mM β-glycerophosphate, 2.5mM DTT, 0.01% Triton™ X-100, 200μM ATP, 200μg/mL Abl1 peptide substrate (EAIYAAPFAKKK) and trace [32P]-γ-ATP for 10 minutes at 30°C
Kinase and inhibitors
EGF receptor (ErbB)
EGFR (ErbB1) [T790M] Recombinant Human Protein
Human
0.29mg/mL
1956
EGFR (ErbB1) [T790M] Recombinant Human Protein
10μg
For research use only. Not for use in diagnostic procedures
Receptor tyrosine kinases
EGFR (ErbB1) [T790M] Recombinant Human Protein
Kinase assay
Baculovirus
Amino acids 668-1210; T790M
43nmoles of phosphate transferred to Abl1 peptide substrate (EAIYAAPFAKKK) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 6.67μg/mL
GST Tag
Documents

For Research Use Only. Not for use in diagnostic procedures.